SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.
The transcriptional corepressor mSin3 is found in a large multiprotein complex containing the histone deacetylases HDAC1 and HDAC2, in addition to at least five tightly associated polypeptides. We have cloned and characterized a novel component of the mSin3 complex, SAP30, SAP30 binds to mSin3 and is capable of mediating transcriptional ... repression via histone deacetylases. SAP30 also binds the N-CoR corepressor and is required for N-CoR-mediated repression by antagonist-bound estrogen receptor and the homeodomain protein Rpx, as well as N-CoR suppression of transactivation by the POU domain protein Pit-1. However, SAP30 is not required for N-CoR-mediated repression by unliganded retinoic acid receptor or thyroid hormone receptor, suggesting that SAP30 is involved in the functional recruitment of the mSin3-histone deacetylase complex to a specific subset of N-CoR corepressor complexes.
Mesh Terms:
Amino Acid Sequence, Animals, Cell Line, Transformed, DNA-Binding Proteins, Histone Deacetylases, Homeodomain Proteins, Humans, Kidney, Macromolecular Substances, Mice, Models, Genetic, Molecular Sequence Data, Multiprotein Complexes, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Receptors, Estrogen, Receptors, Retinoic Acid, Receptors, Thyroid Hormone, Repressor Proteins, Saccharomyces cerevisiae Proteins, Transcription Factor Pit-1, Transcription Factors, Transcription, Genetic, Transfection
Amino Acid Sequence, Animals, Cell Line, Transformed, DNA-Binding Proteins, Histone Deacetylases, Homeodomain Proteins, Humans, Kidney, Macromolecular Substances, Mice, Models, Genetic, Molecular Sequence Data, Multiprotein Complexes, Nuclear Proteins, Nuclear Receptor Co-Repressor 1, Receptors, Estrogen, Receptors, Retinoic Acid, Receptors, Thyroid Hormone, Repressor Proteins, Saccharomyces cerevisiae Proteins, Transcription Factor Pit-1, Transcription Factors, Transcription, Genetic, Transfection
Mol. Cell
Date: Jul. 01, 1998
PubMed ID: 9702189
View in: Pubmed Google Scholar
Download Curated Data For This Publication
3067
Switch View:
- Interactions 2