Saccharomyces cerevisiae (S288c)
TUP1
AAR1, AER2, AMM1, CRT4, CYC9, FLK1, ROX4, SFL2, UMR7, chromatin-silencing transcriptional regulator TUP1, L000002391, YCR084C
General repressor of transcription; forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
GO Process (10)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- histone exchange [IMP]
- negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of mating-type specific transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter by glucose [IMP]
- negative regulation of transcription from RNA polymerase II promoter during mitosis [IMP]
- nucleosome positioning [IDA]
- regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of invasive growth in response to glucose limitation [IMP]
- regulation of response to DNA damage stimulus [IMP]
Gene Ontology Molecular Function- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- histone binding [IDA]
- histone deacetylase binding [IDA, IPI]
- mediator complex binding [IDA, IPI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA]
- ubiquitin binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA, IMP]
- histone binding [IDA]
- histone deacetylase binding [IDA, IPI]
- mediator complex binding [IDA, IPI]
- phosphatidylinositol-3,5-bisphosphate binding [IDA]
- ubiquitin binding [IDA]
Gene Ontology Cellular Component
Download Curated Data for this Protein
31057
559292
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- Interactors 135
- Interactions 211
- Network
- PTM Sites 15