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Saccharomyces cerevisiae (S288c)

BLM10

YFL006W, S000007437, YFL007W

Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200

GO Process (4)

GO Function (2)

GO Component (5)

Gene Ontology Biological Process

proteasome assembly [IGI, IMP]

proteasome core complex import into nucleus [IMP]

regulation of proteasomal protein catabolic process [IDA]

sequestration of proteasome core complex in proteasome storage granule [IMP]

Gene Ontology Molecular Function

peptidase activator activity [IDA]
proteasome binding [IDA, IMP]

Gene Ontology Cellular Component

integral component of membrane [ISM]

proteasome complex [IDA]

proteasome core complex [IDA, IMP]

proteasome storage granule [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31140

559292

Interactors 333
Interactions 422
Network
PTM Sites 21