Saccharomyces cerevisiae (S288c)

CLF1

NTC77, SYF3, L000004628, YLR117C

Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins

GO Process (2)

GO Function (4)

GO Component (6)

Gene Ontology Biological Process

DNA replication initiation [IMP, IPI]

cis assembly of pre-catalytic spliceosome [IMP, IPI]

Gene Ontology Molecular Function

DNA replication origin binding [IDA]
chromatin binding [IDA]
first spliceosomal transesterification activity [IC]
second spliceosomal transesterification activity [IC]

Gene Ontology Cellular Component

Prp19 complex [IDA]

U2-type catalytic step 1 spliceosome [IDA]

U2-type catalytic step 2 spliceosome [IDA]

U2-type post-mRNA release spliceosomal complex [IDA]

U2-type prespliceosome [IDA]

chromatin [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31389

559292

Interactors 291
Interactions 550
Network
PTM Sites 2

Result Summary

CLF1

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA replication origin binding [IDA]chromatin binding [IDA]first spliceosomal transesterification activity [IC]second spliceosomal transesterification activity [IC]

Gene Ontology Cellular Component

DNA replication origin binding [IDA]
chromatin binding [IDA]
first spliceosomal transesterification activity [IC]
second spliceosomal transesterification activity [IC]