BioGRID COVID-19 Coronavirus Curation Project
Search BioGRID for SARS-CoV-2 Protein Interactions | Download SARS-CoV-2 and Coronavirus-Related Interactions

Saccharomyces cerevisiae (S288c)

TOP3

EDR1, DNA topoisomerase 3, L000002321, YLR234W

DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity stimulated by RPA and Sgs1p-Top2p-Rmi1p; involved in telomere stability and regulation of mitotic recombination

GO Process (5)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

DNA topological change [IDA]

mitotic sister chromatid cohesion [IMP]

reciprocal meiotic recombination [IGI, IMP]

regulation of DNA recombination [IMP]

telomere maintenance via telomerase [IMP]

Gene Ontology Molecular Function

DNA topoisomerase activity [IDA]
DNA topoisomerase type I activity [IDA]

Gene Ontology Cellular Component

RecQ helicase-Topo III complex [IDA, IPI]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31503

559292

Interactors 238
Interactions 410
Network
PTM Sites 1