Saccharomyces cerevisiae (S288c)

EST2

TERT, L000003504, YLR318W

Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia

GO Process (2)

GO Function (3)

GO Component (4)

Gene Ontology Biological Process

replicative cell aging [IGI]

telomere maintenance via telomerase [IDA, IMP]

Gene Ontology Molecular Function

telomerase activity [IDA]
telomeric DNA binding [IDA]
telomeric template RNA reverse transcriptase activity [TAS]

Gene Ontology Cellular Component

nucleolus [IDA]

nucleus [IDA]

telomerase catalytic core complex [IDA, IPI]

telomerase holoenzyme complex [IDA, IPI]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31582

559292

Interactors 99
Interactions 185
Network
PTM Sites 2

Result Summary

EST2

Gene Ontology Biological Process

Gene Ontology Molecular Function

telomerase activity [IDA]telomeric DNA binding [IDA]telomeric template RNA reverse transcriptase activity [TAS]

Gene Ontology Cellular Component

telomerase activity [IDA]
telomeric DNA binding [IDA]
telomeric template RNA reverse transcriptase activity [TAS]