Saccharomyces cerevisiae (S288c)

ORM2

YLR350W

Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication

GO Process (3)

GO Function (0)

GO Component (3)

Gene Ontology Biological Process

cellular sphingolipid homeostasis [IMP]

negative regulation of sphingolipid biosynthetic process [IGI, IMP]

response to unfolded protein [IMP, ISS]

Gene Ontology Cellular Component

SPOTS complex [IDA]

endoplasmic reticulum [IDA]

integral component of membrane [ISM]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31612

559292

PTM statistics

Proteins

PTM Sites

Publications

Sumoylation Sites (1)
Phosphorylation Sites (4)
Ubiquitination Sites (4)

Interactors 560
Interactions 1,013
Network
PTM Sites 9

Sites with Multi-PTMs

Displaying 1 protein 1 non-assigned with 9 total post translational modifications

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NP_013454

Orm2p

Length: 216

1
MIDRTKNESP AFEESPLTPN VSNLKPFPSQ SNKISTPVTD HRRRRSSSVI
51
SHVEQETFED ENDQQMLPNM NATWVDQRGA WLIHIVVIVL LRLFYSLFGS
101
TPKWTWTLTN MTYIIGFYIM FHLVKGTPFD FNGGAYDNLT MWEQINDETL
151
YTPTRKFLLI VPIVLFLISN QYYRNDMTLF LSNLAVTVLI GVVPKLGITH
201
RLRISIPGIT GRAQIS

Location	PTM	Residue	Source(s)	Note(s)
6	Ubiquitination	K	Mayor T (2007)	-
9	Phosphorylation	S	Albuquerque CP (2008)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAwLjYzNCwxLjQyMSIsIlBNSUQgMTk4MjM3NTA6IGJlc3QgcHJlZGljdGVkIG1vdGlmID0gQ0sxIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gQ0RDMjgsIGFjY3VtdWxhdGVzIGluIG5hdDMgY2VsbHMuIl19
			Gnad F (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAwLjYzNCwxLjQyMSIsIlBNSUQgMTk4MjM3NTA6IGJlc3QgcHJlZGljdGVkIG1vdGlmID0gQ0sxIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gQ0RDMjgsIGFjY3VtdWxhdGVzIGluIG5hdDMgY2VsbHMuIl19
			Helbig AO (2010)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAwLjYzNCwxLjQyMSIsIlBNSUQgMTk4MjM3NTA6IGJlc3QgcHJlZGljdGVkIG1vdGlmID0gQ0sxIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gQ0RDMjgsIGFjY3VtdWxhdGVzIGluIG5hdDMgY2VsbHMuIl19
			Holt LJ (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAwLjYzNCwxLjQyMSIsIlBNSUQgMTk4MjM3NTA6IGJlc3QgcHJlZGljdGVkIG1vdGlmID0gQ0sxIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gQ0RDMjgsIGFjY3VtdWxhdGVzIGluIG5hdDMgY2VsbHMuIl19
			Smolka MB (2007)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAwLjYzNCwxLjQyMSIsIlBNSUQgMTk4MjM3NTA6IGJlc3QgcHJlZGljdGVkIG1vdGlmID0gQ0sxIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gQ0RDMjgsIGFjY3VtdWxhdGVzIGluIG5hdDMgY2VsbHMuIl19
			Soufi B (2009) [show 1 more ]	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAwLjYzNCwxLjQyMSIsIlBNSUQgMTk4MjM3NTA6IGJlc3QgcHJlZGljdGVkIG1vdGlmID0gQ0sxIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gQ0RDMjgsIGFjY3VtdWxhdGVzIGluIG5hdDMgY2VsbHMuIl19
15	Phosphorylation	S	Gnad F (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAxLjcwNCwxLjE3Ni4iXX0=
			Holt LJ (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAxLjcwNCwxLjE3Ni4iXX0=
			Smolka MB (2007)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAxLjcwNCwxLjE3Ni4iXX0=
			Soufi B (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAxLjcwNCwxLjE3Ni4iXX0=
18	Phosphorylation	T	Gnad F (2009)	eyJOT1RFUyI6WyIxIHBlcHRpZGUgb2NjdXJyZW5jZSBpbiBQTUlEIDE3MzMwOTUwIiwiUE1JRCAxOTgyMzc1MDogNSwyMCBtaW4gMC40TSBOYUNsIHJhdGlvIChsb2cyKTsgMi44NjUsMS4xNzkiLCJQTUlEIDE5ODIzNzUwOiBiZXN0IHByZWRpY3RlZCBtb3RpZiA9IFdXIEdyb3VwSVYuIl19
			Li X (2007)	eyJOT1RFUyI6WyIxIHBlcHRpZGUgb2NjdXJyZW5jZSBpbiBQTUlEIDE3MzMwOTUwIiwiUE1JRCAxOTgyMzc1MDogNSwyMCBtaW4gMC40TSBOYUNsIHJhdGlvIChsb2cyKTsgMi44NjUsMS4xNzkiLCJQTUlEIDE5ODIzNzUwOiBiZXN0IHByZWRpY3RlZCBtb3RpZiA9IFdXIEdyb3VwSVYuIl19
			Soufi B (2009)	eyJOT1RFUyI6WyIxIHBlcHRpZGUgb2NjdXJyZW5jZSBpbiBQTUlEIDE3MzMwOTUwIiwiUE1JRCAxOTgyMzc1MDogNSwyMCBtaW4gMC40TSBOYUNsIHJhdGlvIChsb2cyKTsgMi44NjUsMS4xNzkiLCJQTUlEIDE5ODIzNzUwOiBiZXN0IHByZWRpY3RlZCBtb3RpZiA9IFdXIEdyb3VwSVYuIl19
25	Ubiquitination	K	Mayor T (2007)	-
29	Phosphorylation	S	Helbig AO (2010)	eyJOT1RFUyI6WyJQTUlEIDIxMTI2MzM2OiBQcmVkaWN0ZWQgcHJvdGVpbiBraW5hc2UgPSBTTkYxIl19
33	Ubiquitination	K	Iesmantavicius V (2014)	-
33	Ubiquitination	K	Mayor T (2007)	-

View

Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.

Location	PTM	Residue	Source(s)	Note(s)
-	Sumoylation	K	Hannich JT (2005)	eyJSRUxBVElPTlNISVBTIjp7IlNNVDMiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMyNTYxXC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3NtdDMuaHRtbCcgYWx0PSdTTVQzJz5TTVQzPFwvYT48XC9zcGFuPiJ9fQ==
-	Ubiquitination	K	Duttler S (2013)	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
			Kolawa NJ (2013)	eyJOT1RFUyI6WyJUYWJsZSBTMTsgVmFsaWQgU3Vic3RyYXRlIiwibGlrZWx5IHViaXF1aXRpbiBjb25qdWdhdGUiXSwiUkVMQVRJT05TSElQUyI6eyJVQkMiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzExMzE2NFwvc3VtbWFyeVwvaG9tby1zYXBpZW5zXC91YmMuaHRtbCcgYWx0PSdVQkMnPlVCQzxcL2E+PFwvc3Bhbj4iLCJVQkk0IjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8zMTIxNVwvc3VtbWFyeVwvc2FjY2hhcm9teWNlcy1jZXJldmlzaWFlXC91Ymk0Lmh0bWwnIGFsdD0nVUJJNCc+VUJJNDxcL2E+PFwvc3Bhbj4ifX0=
			Mayor T (2007)	eyJOT1RFUyI6WyJsaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZSJdLCJSRUxBVElPTlNISVBTIjp7IlVCQyI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMTEzMTY0XC9zdW1tYXJ5XC9ob21vLXNhcGllbnNcL3ViYy5odG1sJyBhbHQ9J1VCQyc+VUJDPFwvYT48XC9zcGFuPiIsIlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==
			Peng J (2003)	eyJOT1RFUyI6WyJDYW5kaWRhdGUgdWJpcXVpdGluLWNvbmp1Z2F0ZWQgcHJvdGVpbnMgbGlzdGVkIGluIHN1cHBsZW1lbnRhcnkgdGFibGUgMSBvZiB0aGUgcGFwZXIuIl0sIlJFTEFUSU9OU0hJUFMiOnsiVUJDIjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8xMTMxNjRcL3N1bW1hcnlcL2hvbW8tc2FwaWVuc1wvdWJjLmh0bWwnIGFsdD0nVUJDJz5VQkM8XC9hPjxcL3NwYW4+IiwiVUJJNCI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMzEyMTVcL3N1bW1hcnlcL3NhY2NoYXJvbXljZXMtY2VyZXZpc2lhZVwvdWJpNC5odG1sJyBhbHQ9J1VCSTQnPlVCSTQ8XC9hPjxcL3NwYW4+In19
			Phillips AH (2013)	eyJSRUxBVElPTlNISVBTIjp7IlVCQyI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMTEzMTY0XC9zdW1tYXJ5XC9ob21vLXNhcGllbnNcL3ViYy5odG1sJyBhbHQ9J1VCQyc+VUJDPFwvYT48XC9zcGFuPiIsIlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
SMT3	Conjugate	-	Sumoylation	K	PTM	Hannich JT (2005)
UBI4	Conjugate	-	Ubiquitination	K	PTM	Duttler S (2013)
						Kolawa NJ (2013)
						Mayor T (2007)
						Peng J (2003)
UBC	Conjugate	-	Ubiquitination	K	PTM	Phillips AH (2013)