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Saccharomyces cerevisiae (S288c)

FUN12

yIF2, translation initiation factor eIF5B, eIF5B, L000000635, YAL035W

Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2

GO Process (4)

GO Function (6)

GO Component (5)

Gene Ontology Biological Process

formation of cytoplasmic translation initiation complex [IDA, IMP]

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]

regulation of translational initiation [IMP]

ribosome assembly [IMP]

Gene Ontology Molecular Function

GTP binding [IDA]
GTPase activity [IDA, IMP, ISS]
protein binding [IPI]
ribosome binding [IDA]
translation initiation factor activity [IDA]
translation initiation factor binding [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytosolic small ribosomal subunit [IDA]

eukaryotic 48S preinitiation complex [IDA]

mitochondrion [IDA]

preribosome, large subunit precursor [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31730

559292

Interactors 225
Interactions 308
Network
PTM Sites 20