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Saccharomyces cerevisiae (S288c)

PMT2

FUN25, dolichyl-phosphate-mannose-protein mannosyltransferase PMT2, L000000642, L000001459, YAL023C

Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication

GO Process (5)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

ER-associated misfolded protein catabolic process [IGI, IMP]

protein O-linked glycosylation [IMP]

protein O-linked mannosylation [IGI, IMP]

protein exit from endoplasmic reticulum [IGI]

regulation of endoplasmic reticulum unfolded protein response [IGI, IMP]

Gene Ontology Molecular Function

dolichyl-phosphate-mannose-protein mannosyltransferase activity [IDA, IGI, IMP, ISA]

Gene Ontology Cellular Component

dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [IDA, IPI]

dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex [IDA]

integral component of membrane [ISM]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31743

559292

Interactors 288
Interactions 572
Network
PTM Sites 13