Saccharomyces cerevisiae (S288c)
BRE1
E3 ubiquitin-protein ligase BRE1, YDL074C
E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- chromatin silencing at telomere [IMP]
- double-strand break repair via homologous recombination [IGI]
- histone monoubiquitination [IMP]
- histone ubiquitination [IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic DNA double-strand break formation [IMP]
- mitotic G1 DNA damage checkpoint [IMP]
- regulation of DNA-dependent DNA replication initiation [IMP]
- telomere maintenance via recombination [IGI]
- transcription from RNA polymerase II promoter [IGI, IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
31987
559292
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- Interactors 850
- Interactions 1,596
- Network
- PTM Sites 2