Saccharomyces cerevisiae (S288c)
DOA4
DOS1, MUT4, NPI2, SSV7, UBP4, L000000514, YDR069C
Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication
GO Process (7)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- endocytosis [IMP]
- free ubiquitin chain depolymerization [IDA]
- intralumenal vesicle formation [IGI]
- regulation of DNA replication [IMP]
- ubiquitin homeostasis [IMP]
- ubiquitin-dependent protein catabolic process [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
32124
559292
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- Interactors 302
- Interactions 389
- Network
- PTM Sites 6