Saccharomyces cerevisiae (S288c)

MSH6

PMS3, PMS6, mismatch repair ATPase MSH6, L000003135, L000004503, S000029377, YDR097C

Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p

GO Process (7)

GO Function (7)

GO Component (4)

Gene Ontology Biological Process

interstrand cross-link repair [IGI]

maintenance of DNA repeat elements [IBA]

meiotic mismatch repair [IMP]

mismatch repair [IDA, IMP]

negative regulation of DNA recombination [IBA]

reciprocal meiotic recombination [IBA]

response to UV [IBA]

Gene Ontology Molecular Function

ATP binding [IDA]
ATPase activity [IDA]
DNA-dependent ATPase activity [IBA]
damaged DNA binding [IBA]
four-way junction DNA binding [IDA]
guanine/thymine mispair binding [IDA]
single base insertion or deletion binding [IDA, IMP]

Gene Ontology Cellular Component

MutSalpha complex [IPI]

cytoplasm [IDA]

nuclear chromosome [IBA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

32152

559292

Interactors 133
Interactions 271
Network
PTM Sites 20

Result Summary

MSH6

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [IDA]ATPase activity [IDA]DNA-dependent ATPase activity [IBA]damaged DNA binding [IBA]four-way junction DNA binding [IDA]guanine/thymine mispair binding [IDA]single base insertion or deletion binding [IDA, IMP]

Gene Ontology Cellular Component

ATP binding [IDA]
ATPase activity [IDA]
DNA-dependent ATPase activity [IBA]
damaged DNA binding [IBA]
four-way junction DNA binding [IDA]
guanine/thymine mispair binding [IDA]
single base insertion or deletion binding [IDA, IMP]