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Saccharomyces cerevisiae (S288c)

RPB7

DNA-directed RNA polymerase II subunit RPB7, B16, L000001681, YDR404C

RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation

GO Process (5)

GO Function (4)

GO Component (4)

Gene Ontology Biological Process

nuclear-transcribed mRNA catabolic process, exonucleolytic [IGI]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [IMP]

positive regulation of translational initiation [IMP]

transcription from RNA polymerase II promoter [IGI]

transcription initiation from RNA polymerase II promoter [IDA]

Gene Ontology Molecular Function

RNA-directed RNA polymerase activity [IDA]
single-stranded DNA binding [IDA, IMP]
single-stranded RNA binding [IDA, IMP]
translation initiation factor binding [IPI]

Gene Ontology Cellular Component

DNA-directed RNA polymerase II, core complex [IDA]

cytoplasm [IDA]

cytoplasmic mRNA processing body [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

32464

559292

Interactors 379
Interactions 596
Network
PTM Sites 5