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Saccharomyces cerevisiae (S288c)

NHX1

NHA2, VPL27, VPS44, bifunctional K:H/Na:H antiporter NHX1, L000004336, YDR456W

Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism

GO Process (4)

GO Function (2)

GO Component (5)

Gene Ontology Biological Process

cellular monovalent inorganic cation homeostasis [IMP]

potassium ion transmembrane transport [IMP]

sodium ion transmembrane transport [IMP]

vacuolar acidification [IMP]

Gene Ontology Molecular Function

potassium:proton antiporter activity [IMP]
sodium:proton antiporter activity [IMP]

Gene Ontology Cellular Component

early endosome [IDA]

fungal-type vacuole membrane [IDA]

integral component of membrane [ISM]

late endosome [IDA]

trans-Golgi network [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

32510

559292

Interactors 292
Interactions 360
Network
PTM Sites 5