Saccharomyces cerevisiae (S288c)


GLC1, PPD1, L000000704, L000000873, YBR140C
GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis
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  • Interactors 59
  • Interactions 78
  • Network
  • PTM Sites 16