Saccharomyces cerevisiae (S288c)


HRD4, L000001271, YBR170C
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
Download Curated Data for this Protein
Switch View:
  • Interactors 279
  • Interactions 374
  • Network
  • PTM Sites 12