Saccharomyces cerevisiae (S288c)
ISW1
SGN2, chromatin-remodeling ATPase ISW1, L000004447, YBR245C
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK
GO Process (11)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- DNA-templated transcription, elongation [IDA, IMP]
- chromatin organization involved in regulation of transcription [IMP]
- chromatin remodeling [IGI, IMP, IPI]
- heterochromatin maintenance involved in chromatin silencing [IGI, IMP]
- negative regulation of histone exchange [IMP]
- nucleosome positioning [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of chromatin organization [IMP]
- regulation of transcriptional start site selection at RNA polymerase II promoter [IGI]
- termination of RNA polymerase I transcription [IGI]
- termination of RNA polymerase II transcription [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
32940
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- Interactors 1,907
- Interactions 2,223
- Network
- PTM Sites 16