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Saccharomyces cerevisiae (S288c)

ESP1

L000000584, YGR098C

Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress

GO Process (5)

GO Function (1)

GO Component (4)

Gene Ontology Biological Process

apoptotic process [IMP]

mitotic sister chromatid segregation [IMP, IPI]

negative regulation of protein phosphatase type 2A activity [IMP, IPI]

regulation of exit from mitosis [IGI, IPI]

regulation of mitotic spindle elongation [IGI, IMP]

Gene Ontology Molecular Function

cysteine-type endopeptidase activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

mitochondrion [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

33341

559292

Interactors 591
Interactions 685
Network
PTM Sites 1