Saccharomyces cerevisiae (S288c)

PRS1

PRP1, ribose phosphate diphosphokinase subunit PRS1, L000001494, YKL181W
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease
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  • Interactors 51
  • Interactions 68
  • Network
  • PTM Sites 12