Saccharomyces cerevisiae (S288c)

URA1

dihydroorotate dehydrogenase, L000002430, YKL216W

Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid

GO Process (1)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

'de novo' pyrimidine nucleobase biosynthetic process [IDA, IMP]

Gene Ontology Molecular Function

dihydroorotate dehydrogenase activity [IDA, IMP]

Gene Ontology Cellular Component

cytoplasm [IDA]

extrinsic component of membrane [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

33949

559292

PTM statistics

Proteins

PTM Sites

Publications

Sumoylation Sites (1)
Phosphorylation Sites (1)
Ubiquitination Sites (4)

Interactors 117
Interactions 134
Network
PTM Sites 6

Sites with Multi-PTMs

Displaying 1 protein 1 non-assigned with 6 total post translational modifications

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NP_012706

dihydroorotate dehydrogenase

Length: 314

1
MTASLTTKFL NNTYENPFMN ASGVHCMTTQ ELDELANSKA GAFITKSATT
51
LEREGNPEPR YISVPLGSIN SMGLPNEGID YYLSYVLNRQ KNYPDAPAIF
101
FSVAGMSIDE NLNLLRKIQD SEFNGITELN LSCPNVPGKP QVAYDFDLTK
151
ETLEKVFAFF KKPLGVKLPP YFDFAHFDIM AKILNEFPLA YVNSINSIGN
201
GLFIDVEKES VVVKPKNGFG GIGGEYVKPT ALANVRAFYT RLRPEIKVIG
251
TGGIKSGKDA FEHLLCGASM LQIGTELQKE GVKIFERIEK ELKDIMEAKG
301
YTSIDQFRGK LNSI

Location	PTM	Residue	Source(s)	Note(s)
2	Phosphorylation	T	Helbig AO (2010)	eyJOT1RFUyI6WyJQTUlEIDIxMTI2MzM2OiBQcmVkaWN0ZWQgcHJvdGVpbiBraW5hc2UgPSBDREMyOCJdfQ==
46	Ubiquitination	K	Beltrao P (2012)	-
			Iesmantavicius V (2014)	-
			Starita LM (2011)	-
			Swaney DL (2013)	-
247	Ubiquitination	K	Beltrao P (2012)	-
247	Ubiquitination	K	Iesmantavicius V (2014)	-
293	Ubiquitination	K	Swaney DL (2013)	-

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Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.

Location	PTM	Residue	Source(s)	Note(s)
-	Sumoylation	K	Sung MK (2013)	eyJOT1RFUyI6WyJiaW1vbGVjdWxhciBmbHVvcmVzY2VuY2UgY29tcGxlbWVudGF0aW9uIChCaUZDKSBhc3NheTsgQ292YWxlbnQgIG1vZGlmaWNhdGlvbiJdLCJSRUxBVElPTlNISVBTIjp7IlNNVDMiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMyNTYxXC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3NtdDMuaHRtbCcgYWx0PSdTTVQzJz5TTVQzPFwvYT48XC9zcGFuPiJ9fQ==
-	Sumoylation	K	Wohlschlegel JA (2004)	eyJOT1RFUyI6WyJIaXMtdGFnZ2VkIFNtdDNwIChTVU1PKSB3YXMgdXNlZCB0byBpZGVudGlmeSBzdW1veWxhdGVkIHN1YnN0cmF0ZXMuIl0sIlJFTEFUSU9OU0hJUFMiOnsiU01UMyI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMzI1NjFcL3N1bW1hcnlcL3NhY2NoYXJvbXljZXMtY2VyZXZpc2lhZVwvc210My5odG1sJyBhbHQ9J1NNVDMnPlNNVDM8XC9hPjxcL3NwYW4+In19
-	Ubiquitination	K	Starita LM (2011)	eyJOT1RFUyI6WyJMaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZXMiLCJDYW5kaWRhdGUgdWJpcXVpdGluIHN1YnN0cmF0ZXMgd2VyZSBpZGVudGlmaWVkIHVzaW5nIHViaXF1aXRpbiByZW1uYW50IGltbXVub2FmZmluaXR5IHByb2ZpbGluZy4iXSwiUkVMQVRJT05TSElQUyI6eyJVQkk0IjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8zMTIxNVwvc3VtbWFyeVwvc2FjY2hhcm9teWNlcy1jZXJldmlzaWFlXC91Ymk0Lmh0bWwnIGFsdD0nVUJJNCc+VUJJNDxcL2E+PFwvc3Bhbj4ifX0=
			Swaney DL (2013)	eyJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==
			Ziv I (2011)	eyJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
SMT3	Conjugate	-	Sumoylation	K	PTM	Sung MK (2013)
SMT3	Conjugate	-	Sumoylation	K	PTM	Wohlschlegel JA (2004)
UBI4	Conjugate	-	Ubiquitination	K	PTM	Starita LM (2011)
						Swaney DL (2013)
						Ziv I (2011)

Result Summary