Saccharomyces cerevisiae (S288c)

DOA1

UFD3, ZZZ4, L000002961, YKL213C
WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 (Cse4p) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
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  • Interactors 700
  • Interactions 1,229
  • Network
  • PTM Sites 17