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Saccharomyces cerevisiae (S288c)

RRN3

L000003362, YKL125W

Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo

GO Process (1)

GO Function (5)

GO Component (1)

Gene Ontology Biological Process

transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript [IMP]

Gene Ontology Molecular Function

RNA polymerase I core binding [IDA, IPI]
RNA polymerase I transcription factor binding [IDA, IPI]
RNA polymerase I transcription factor binding transcription factor activity [IDA, IGI, IPI]
core RNA polymerase I binding transcription factor activity [IDA, IGI, IPI]
rDNA binding [IDA]

Gene Ontology Cellular Component

nucleolus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

34011

559292

Interactors 159
Interactions 190
Network
PTM Sites 1