Saccharomyces cerevisiae (S288c)
IRA2
CCS1, GLC4, Ras GTPase activating protein IRA2, L000000874, YOL081W
GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis
GO Process (7)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- cellular response to cold [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to metal ion [IMP]
- cellular response to oxidative stress [IMP]
- negative regulation of Ras protein signal transduction [IMP]
- negative regulation of cAMP biosynthetic process [IMP]
- positive regulation of Ras GTPase activity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
34321
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- Interactors 1,001
- Interactions 1,706
- Network
- PTM Sites 21