RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we ... have called receptor-activity-modifying proteins or RAMPs, are expressed. RAMPs are required to transport CRLR to the plasma membrane. RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors.
Mesh Terms:
3T3 Cells, Adrenomedullin, Amino Acid Sequence, Animals, Biological Transport, Calcitonin, Calcitonin Gene-Related Peptide, Cell Line, Cloning, Molecular, Cross-Linking Reagents, Cystic Fibrosis Transmembrane Conductance Regulator, Gene Expression, Glycosylation, Humans, Intracellular Signaling Peptides and Proteins, Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase, Membrane Proteins, Mice, Molecular Sequence Data, Peptides, RNA, Messenger, Receptors, Calcitonin, Receptors, Calcitonin Gene-Related Peptide, Receptors, Peptide, Sequence Alignment, Tumor Cells, Cultured, Xenopus
3T3 Cells, Adrenomedullin, Amino Acid Sequence, Animals, Biological Transport, Calcitonin, Calcitonin Gene-Related Peptide, Cell Line, Cloning, Molecular, Cross-Linking Reagents, Cystic Fibrosis Transmembrane Conductance Regulator, Gene Expression, Glycosylation, Humans, Intracellular Signaling Peptides and Proteins, Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase, Membrane Proteins, Mice, Molecular Sequence Data, Peptides, RNA, Messenger, Receptors, Calcitonin, Receptors, Calcitonin Gene-Related Peptide, Receptors, Peptide, Sequence Alignment, Tumor Cells, Cultured, Xenopus
Nature
Date: May. 28, 1998
PubMed ID: 9620797
View in: Pubmed Google Scholar
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