Saccharomyces cerevisiae (S288c)


SIZ2, SUMO ligase NFI1, L000002966, YOR156C
SUMO E3 ligase; catalyzes sumoylation of Yku70p/Yku80p and Sir4p promoting chromatin anchoring; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length; NFI1 has a paralog, SIZ1, that arose from the whole genome duplication
GO Process (3)
GO Function (2)
GO Component (3)

External Database Linkouts

SGD | Entrez Gene | RefSeq | UniprotKB
Download 289 Published Interactions For This Protein
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  • Interactors (204)
  • Interactions (289)
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  • PTM Sites (4)