Saccharomyces cerevisiae (S288c)

GCD1

TRA3, L000000670, YOR260W

Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression

GO Process (1)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

regulation of translational initiation [IDA, IGI, IMP]

Gene Ontology Molecular Function

guanyl-nucleotide exchange factor activity [IDA, IPI]
translation initiation factor activity [IMP, IPI]

Gene Ontology Cellular Component

eukaryotic translation initiation factor 2B complex [IDA]

guanyl-nucleotide exchange factor complex [IDA, IPI]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

34650

559292

PTM statistics

Proteins

PTM Sites

Publications

Phosphorylation Sites (4)
Ubiquitination Sites (1)

Interactors 410
Interactions 556
Network
PTM Sites 5

Sites with Multi-PTMs

Displaying 1 protein 1 non-assigned with 5 total post translational modifications

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NP_014903

Gcd1p

Length: 578

1
MSIQAFVFCG KGSNLAPFTQ PDFPFQTQNK DSTAATSGDK LNELVNSALD
51
STVINEFMQH STRLPKALLP IGNRPMIEYV LDWCDQADFK EISVVAPVDE
101
IELIESGLTS FLSLRKQQFE LIYKALSNSN HSHHLQDPKK INFIPSKANS
151
TGESLQKELL PRINGDFVIL PCDFVTDIPP QVLVDQFRNR DDNNLAMTIY
201
YKNSLDSSID KKQQQKQKQQ QFFTVYSENE DSERQPILLD VYSQRDVTKT
251
KYLQIRSHLL WNYPNLTVST KLLNSFIYFC SFELCQLLKL GPQSMSRQAS
301
FKDPFTGNQQ QQNPPTTDDD EDRNHDDDDD YKPSATSIQP TYFKKKNDLI
351
LDPINCNKSL SKVFRDLSRR SWQHSKPREP IGIFILPNET LFIRANNLNA
401
YMDANRFVLK IKSQTMFTKN IQIQSAAIGA DAIVDPKCQI SAHSNVKMSV
451
LGTQANIGSR CRVAGSLLFP GVHLGDEVIL ENCIIGPMAK IGSKCKLSNC
501
YIEGHYVVEP KNNFKGETLA NVYLDEDEED ELIYDDSVIA GESEIAEETD
551
SDDRSDEDSD DSEYTDEYEY EDDGLFER

Location	PTM	Residue	Source(s)	Note(s)
294	Phosphorylation	S	Bodenmiller B (2010)	eyJOT1RFUyI6WyJQb3NzaWJsZSBzaXRlIGZvciBDREssIFBNSUQgMTk3OTU0MjMiLCJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC44MTcsLTAuOTM2IiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUEtDMSIsIkRlbGV0aW9uIG9mIHByb3RlaW4gS2luYXNlIFlLTDEyNldcL1lQSzEgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjU5OSAtIFBNSUQgMjExNzc0OTUuIl19
			Gnad F (2009)	eyJOT1RFUyI6WyJQb3NzaWJsZSBzaXRlIGZvciBDREssIFBNSUQgMTk3OTU0MjMiLCJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC44MTcsLTAuOTM2IiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUEtDMSIsIkRlbGV0aW9uIG9mIHByb3RlaW4gS2luYXNlIFlLTDEyNldcL1lQSzEgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjU5OSAtIFBNSUQgMjExNzc0OTUuIl19
			Helbig AO (2010)	eyJOT1RFUyI6WyJQb3NzaWJsZSBzaXRlIGZvciBDREssIFBNSUQgMTk3OTU0MjMiLCJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC44MTcsLTAuOTM2IiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUEtDMSIsIkRlbGV0aW9uIG9mIHByb3RlaW4gS2luYXNlIFlLTDEyNldcL1lQSzEgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjU5OSAtIFBNSUQgMjExNzc0OTUuIl19
			Soufi B (2009)	eyJOT1RFUyI6WyJQb3NzaWJsZSBzaXRlIGZvciBDREssIFBNSUQgMTk3OTU0MjMiLCJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC44MTcsLTAuOTM2IiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUEtDMSIsIkRlbGV0aW9uIG9mIHByb3RlaW4gS2luYXNlIFlLTDEyNldcL1lQSzEgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjU5OSAtIFBNSUQgMjExNzc0OTUuIl19
			Soulard A (2010)	eyJOT1RFUyI6WyJQb3NzaWJsZSBzaXRlIGZvciBDREssIFBNSUQgMTk3OTU0MjMiLCJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC44MTcsLTAuOTM2IiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUEtDMSIsIkRlbGV0aW9uIG9mIHByb3RlaW4gS2luYXNlIFlLTDEyNldcL1lQSzEgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjU5OSAtIFBNSUQgMjExNzc0OTUuIl19
296	Phosphorylation	S	Bodenmiller B (2010)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC4wNDQsLTAuMjEzIiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBHU0szIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUklNMTEiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlCUjEyNUNcL1BUQzQgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjUwNiAtIFBNSUQgMjExNzc0OTUiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlEUjA3NVdcL1BQSDMgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIDEuNTM4IC0gUE1JRCAyMTE3NzQ5NS4iXX0=
			Chi A (2007)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC4wNDQsLTAuMjEzIiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBHU0szIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUklNMTEiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlCUjEyNUNcL1BUQzQgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjUwNiAtIFBNSUQgMjExNzc0OTUiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlEUjA3NVdcL1BQSDMgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIDEuNTM4IC0gUE1JRCAyMTE3NzQ5NS4iXX0=
			Gnad F (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC4wNDQsLTAuMjEzIiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBHU0szIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUklNMTEiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlCUjEyNUNcL1BUQzQgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjUwNiAtIFBNSUQgMjExNzc0OTUiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlEUjA3NVdcL1BQSDMgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIDEuNTM4IC0gUE1JRCAyMTE3NzQ5NS4iXX0=
			Gruhler A (2005)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC4wNDQsLTAuMjEzIiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBHU0szIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUklNMTEiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlCUjEyNUNcL1BUQzQgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjUwNiAtIFBNSUQgMjExNzc0OTUiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlEUjA3NVdcL1BQSDMgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIDEuNTM4IC0gUE1JRCAyMTE3NzQ5NS4iXX0=
			Helbig AO (2010)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC4wNDQsLTAuMjEzIiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBHU0szIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUklNMTEiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlCUjEyNUNcL1BUQzQgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjUwNiAtIFBNSUQgMjExNzc0OTUiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlEUjA3NVdcL1BQSDMgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIDEuNTM4IC0gUE1JRCAyMTE3NzQ5NS4iXX0=
			Soufi B (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC4wNDQsLTAuMjEzIiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBHU0szIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUklNMTEiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlCUjEyNUNcL1BUQzQgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjUwNiAtIFBNSUQgMjExNzc0OTUiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlEUjA3NVdcL1BQSDMgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIDEuNTM4IC0gUE1JRCAyMTE3NzQ5NS4iXX0=
			Soulard A (2010) [show 2 more ]	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC4wNDQsLTAuMjEzIiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBHU0szIiwiUE1JRCAyMTEyNjMzNjogUHJlZGljdGVkIHByb3RlaW4ga2luYXNlID0gUklNMTEiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlCUjEyNUNcL1BUQzQgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIC0yLjUwNiAtIFBNSUQgMjExNzc0OTUiLCJEZWxldGlvbiBvZiBwcm90ZWluIFBob3NwaGF0YXNlIFlEUjA3NVdcL1BQSDMgY2F1c2VzIEZvbGQgQ2hhbmdlIGxvZ0ZDIDEuNTM4IC0gUE1JRCAyMTE3NzQ5NS4iXX0=
300	Phosphorylation	S	Chi A (2007)	-
306	Phosphorylation	T	Holt LJ (2009)	-

View

Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.

Location	PTM	Residue	Source(s)	Note(s)
-	Ubiquitination	K	Duttler S (2013)	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
			Kolawa NJ (2013)	eyJOT1RFUyI6WyJUYWJsZSBTMTsgVmFsaWQgU3Vic3RyYXRlIiwibGlrZWx5IHViaXF1aXRpbiBjb25qdWdhdGUiXSwiUkVMQVRJT05TSElQUyI6eyJVQkMiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzExMzE2NFwvc3VtbWFyeVwvaG9tby1zYXBpZW5zXC91YmMuaHRtbCcgYWx0PSdVQkMnPlVCQzxcL2E+PFwvc3Bhbj4iLCJVQkk0IjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8zMTIxNVwvc3VtbWFyeVwvc2FjY2hhcm9teWNlcy1jZXJldmlzaWFlXC91Ymk0Lmh0bWwnIGFsdD0nVUJJNCc+VUJJNDxcL2E+PFwvc3Bhbj4ifX0=
			Phillips AH (2013)	eyJSRUxBVElPTlNISVBTIjp7IlVCQyI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMTEzMTY0XC9zdW1tYXJ5XC9ob21vLXNhcGllbnNcL3ViYy5odG1sJyBhbHQ9J1VCQyc+VUJDPFwvYT48XC9zcGFuPiIsIlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
UBI4	Conjugate	-	Ubiquitination	K	PTM	Duttler S (2013)
UBI4	Conjugate	-	Ubiquitination	K	PTM	Kolawa NJ (2013)
UBC	Conjugate	-	Ubiquitination	K	PTM	Phillips AH (2013)

Result Summary