Saccharomyces cerevisiae (S288c)

SSL2

LOM3, RAD25, TFIIH/NER complex ATPase/helicase subunit SSL2, L000002086, YIL143C
Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to the cytosol in response to hypoxia; homolog of human ERCC3
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  • Interactors 130
  • Interactions 170
  • Network
  • PTM Sites 19