Saccharomyces cerevisiae (S288c)


NPI46, peptidylprolyl isomerase FPR3, L000001268, YML074C
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication
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  • Interactors 138
  • Interactions 164
  • Network
  • PTM Sites 8