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Saccharomyces cerevisiae (S288c)

UBX2

SEL1, YML013W

Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis

GO Process (3)

GO Function (1)

GO Component (7)

Gene Ontology Biological Process

ER-associated ubiquitin-dependent protein catabolic process [IMP, IPI]

lipid particle organization [IGI, IMP]

proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]

Gene Ontology Molecular Function

protein binding, bridging [IPI]

Gene Ontology Cellular Component

Doa10p ubiquitin ligase complex [IDA]

Hrd1p ubiquitin ligase ERAD-L complex [IDA]

endoplasmic reticulum [IDA]

integral component of endoplasmic reticulum membrane [IDA]

integral component of plasma membrane [IDA]

lipid particle [IDA]

mitochondrial outer membrane [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

35156

559292

Interactors 411
Interactions 648
Network
PTM Sites 25