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Saccharomyces cerevisiae (S288c)

MOT3

ROX7, [MOT3], [MOT3+], L000002675, YMR070W

Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth and ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; relocalizes to the cytosol in response to hypoxia; can form [MOT3+] prion

GO Process (4)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

cellular hyperosmotic response [IMP]

negative regulation of ergosterol biosynthetic process [IMP]

negative regulation of transcription from RNA polymerase II promoter [IMP]

positive regulation of transcription from RNA polymerase II promoter [IMP]

Gene Ontology Molecular Function

RNA polymerase II activating transcription factor binding [IPI]
RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II repressing transcription factor binding [IMP]

Gene Ontology Cellular Component

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

35245

559292

Interactors 336
Interactions 453
Network
PTM Sites 13