Saccharomyces cerevisiae (S288c)

TOF1

L000004244, YNL273W

Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia

GO Process (7)

GO Function (0)

GO Component (5)

Gene Ontology Biological Process

DNA repair [IGI, IMP]

DNA replication [IMP]

DNA replication checkpoint [IMP, IPI]

maintenance of DNA repeat elements [IMP]

mitotic sister chromatid cohesion [IGI, IMP]

replication fork arrest [IMP]

replication fork protection [IMP]

Gene Ontology Cellular Component

nuclear chromosome [IPI]

nuclear replication fork [IDA]

replication fork protection complex [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

35567

559292

Interactors 337
Interactions 737
Network
PTM Sites 13