Saccharomyces cerevisiae (S288c)

ASI3

putative ubiquitin-protein ligase ASI3, YNL008C
Subunit of the nuclear inner membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by targeting latent unprocessed forms of Stp1p and Stp2p and maintains the repressed state of gene expression in the absence of inducing amino acids; ASI3 has a paralog, ASI1, that arose from the whole genome duplication
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  • Interactors 125
  • Interactions 155
  • Network
  • PTM Sites 2