Saccharomyces cerevisiae (S288c)

SIS1

type II HSP40 co-chaperone SIS1, L000001898, YNL007C
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1
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  • Interactors 292
  • Interactions 384
  • Network
  • PTM Sites 12