Saccharomyces cerevisiae (S288c)

NOP53

RRP16, YPL146C

Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired

GO Process (3)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]

rRNA processing [IMP]

ribosomal large subunit export from nucleus [IMP]

Gene Ontology Molecular Function

rRNA binding [IDA]

Gene Ontology Cellular Component

nucleolus [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

36037

559292

PTM statistics

Proteins

PTM Sites

Publications

Phosphorylation Sites (4)

Interactors 396
Interactions 575
Network
PTM Sites 4

Sites with Multi-PTMs

Displaying 1 protein with 4 total post translational modifications

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NP_015179

Nop53p

Length: 455

1
MAPTNLTKKP SQYKQSSRKG KKAWRKNIDL SDVEQYMEKK IDHEITHGTS
51
DITSLQNDAL FHVDVEGDEI LKNKLIKRKQ IKKVLKSKEI LDAVKTNSKI
101
AALNHHKNSS GNPNKIQGVS KHELKKLMAL AGRVHGESKI KNRVAKDGLV
151
KTTAGDLWGE ESNSKKQKVK LPSGIKLDVE KKDQIPEELL KKSTTSWSTA
201
SVRPSTLDIE PIAVKEFTEI PHAGKSYNPN NKAWSELINK EYKEEKARED
251
ERIALEKYKE RIRHLMETLD DNEEEESSSN EEEEEEEEEN ENENESTQCS
301
GSDKEIKLSI NKPVKNKKKT KYQRNKAKRH EEKVKLQQEL KELRQRVKDL
351
EEVINSEETE ILSAIESDSN KVKKSKKNKK HKLGTKYSVI DERLEIKFSD
401
ELSDSLRKLK PEGNLLYDTV RKLQSSGKVE TRVPVRKGRK YKQKITEKWT
451
HKDFK

Location	PTM	Residue	Source(s)	Note(s)
31	Phosphorylation	S	Albuquerque CP (2008)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC42OTEsLTAuOTY1IiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBDSzIuIl19
			Gnad F (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC42OTEsLTAuOTY1IiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBDSzIuIl19
			Holt LJ (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC42OTEsLTAuOTY1IiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBDSzIuIl19
			Huber A (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC42OTEsLTAuOTY1IiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBDSzIuIl19
			Smolka MB (2007)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC42OTEsLTAuOTY1IiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBDSzIuIl19
			Soufi B (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC42OTEsLTAuOTY1IiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBDSzIuIl19
			Soulard A (2010) [show 2 more ]	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAtMC42OTEsLTAuOTY1IiwiUE1JRCAxOTgyMzc1MDogYmVzdCBwcmVkaWN0ZWQgbW90aWYgPSBDSzIuIl19
173	Phosphorylation	S	Gnad F (2009)	-
173	Phosphorylation	S	Soufi B (2009)	-
363	Phosphorylation	S	Gnad F (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAwLjAzMywtMC41MjQiLCJQTUlEIDE5ODIzNzUwOiBiZXN0IHByZWRpY3RlZCBtb3RpZiA9IENLMi4iXX0=
363	Phosphorylation	S	Soufi B (2009)	eyJOT1RFUyI6WyJQTUlEIDE5ODIzNzUwOiA1LDIwIG1pbiAwLjRNIE5hQ2wgcmF0aW8gKGxvZzIpOyAwLjAzMywtMC41MjQiLCJQTUlEIDE5ODIzNzUwOiBiZXN0IHByZWRpY3RlZCBtb3RpZiA9IENLMi4iXX0=
405	Phosphorylation	S	Bodenmiller B (2010)	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