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Saccharomyces cerevisiae (S288c)

UME1

WTM3, L000003500, YPL139C

Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication

GO Process (4)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

negative regulation of chromatin silencing at telomere [IMP]

negative regulation of transcription from RNA polymerase I promoter [IMP]

positive regulation of transcription from RNA polymerase II promoter [IMP]

regulation of meiosis [IGI]

Gene Ontology Molecular Function

transcription corepressor activity [IDA]

Gene Ontology Cellular Component

Rpd3L complex [IDA]

Rpd3L-Expanded complex [IDA]

Rpd3S complex [IDA]

cytoplasm [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

36043

559292

Interactors 309
Interactions 464
Network
PTM Sites 3