Saccharomyces cerevisiae (S288c)


guanine nucleotide exchange factor MUK1, YPL070W
Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain
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  • Interactors 100
  • Interactions 129
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  • PTM Sites 20