Saccharomyces cerevisiae (S288c)

GLN1

glutamate--ammonia ligase, L000000709, YPR035W
Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
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  • Interactors 138
  • Interactions 155
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  • PTM Sites 19