Saccharomyces cerevisiae (S288c)

TIF5

SUI5, translation initiation factor eIF5, L000002305, YPR041W

Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2

GO Process (4)

GO Function (5)

GO Component (3)

Gene Ontology Biological Process

formation of cytoplasmic translation initiation complex [IDA]

mature ribosome assembly [IMP]

negative regulation of translational initiation [IGI, IMP]

regulation of translational initiation [IDA, IMP, IPI]

Gene Ontology Molecular Function

GDP-dissociation inhibitor activity [IDA, IMP]
GTPase activator activity [IPI, ISS]
protein binding [IPI]
translation initiation factor activity [IDA, ISS]
translation initiation factor binding [IDA, IPI]

Gene Ontology Cellular Component

cytosolic small ribosomal subunit [IPI]

eukaryotic 48S preinitiation complex [IDA]

multi-eIF complex [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

36218

559292

Interactors 124
Interactions 287
Network
PTM Sites 28

Result Summary

TIF5

Gene Ontology Biological Process

Gene Ontology Molecular Function

GDP-dissociation inhibitor activity [IDA, IMP]GTPase activator activity [IPI, ISS]protein binding [IPI]translation initiation factor activity [IDA, ISS]translation initiation factor binding [IDA, IPI]

Gene Ontology Cellular Component

GDP-dissociation inhibitor activity [IDA, IMP]
GTPase activator activity [IPI, ISS]
protein binding [IPI]
translation initiation factor activity [IDA, ISS]
translation initiation factor binding [IDA, IPI]