Saccharomyces cerevisiae (S288c)

FHL1

SPP42, L000000612, YPR104C

Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants

GO Process (3)

GO Function (5)

GO Component (5)

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

36270

559292

Interactors 213
Interactions 230
Network
PTM Sites 10

Result Summary

FHL1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
RNA polymerase II transcription coactivator binding [IPI]
RNA polymerase II transcription corepressor binding [IPI]
double-stranded DNA binding [IBA]
sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

Result Summary

FHL1

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]RNA polymerase II transcription coactivator binding [IPI]RNA polymerase II transcription corepressor binding [IPI]double-stranded DNA binding [IBA]sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IBA]
RNA polymerase II transcription coactivator binding [IPI]
RNA polymerase II transcription corepressor binding [IPI]
double-stranded DNA binding [IBA]
sequence-specific DNA binding [IDA]