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Saccharomyces cerevisiae (S288c)

PRP8

DBF3, DNA39, RNA8, SLT21, USA2, U4/U6-U5 snRNP complex component PRP8, L000001500, L000003226, YHR165C

Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in its human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome.

GO Process (3)

GO Function (7)

GO Component (3)

Gene Ontology Biological Process

generation of catalytic spliceosome for second transesterification step [IMP]

mRNA 3'-splice site recognition [IMP]

spliceosomal tri-snRNP complex assembly [IDA, IMP]

Gene Ontology Molecular Function

U1 snRNA binding [IDA]
U2 snRNA binding [IDA]
U5 snRNA binding [IDA]
U6 snRNA binding [IDA]
mRNA binding [IDA]
pre-mRNA intronic binding [IDA]
second spliceosomal transesterification activity [IMP]

Gene Ontology Cellular Component

U4/U6 x U5 tri-snRNP complex [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

36599

559292

Interactors 258
Interactions 537
Network
PTM Sites 2