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Saccharomyces cerevisiae (S288c)

DNF1

aminophospholipid-translocating P4-type ATPase DNF1, YER166W

Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication

GO Process (5)

GO Function (2)

GO Component (5)

Gene Ontology Biological Process

endocytosis [IGI, IMP]

establishment or maintenance of cell polarity [IGI]

intracellular protein transport [IGI]

phospholipid translocation [IGI, IMP]

response to pheromone involved in conjugation with cellular fusion [IGI]

Gene Ontology Molecular Function

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [IMP, ISS]
phospholipid-translocating ATPase activity [IGI, IMP]

Gene Ontology Cellular Component

Lem3p-Dnf1p complex [IPI]

integral component of membrane [ISM]

mating projection tip membrane [IDA]

mitochondrion [IDA]

plasma membrane [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

36919

559292

Interactors 157
Interactions 201
Network
PTM Sites 35