Saccharomyces cerevisiae (S288c)


KDM4, L000004504, YER169W
JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNAP II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; target of stess-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication

External Database Linkouts

SGD | Entrez Gene | RefSeq | UniprotKB
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  • Interactors (134)
  • Interactions (140)
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  • PTM Sites (22)