Caenorhabditis elegans

HOMT-1

CELE_Y74C9A.3, Y74C9A.3
homt-1 encodes a putative hydroxyindole-O-methyltransferase orthologous to human C1orf184 and C9orf32; by homology, HOMT-1 is expected to catalyze the conversion of N-acetyl serotonin to melatonin; homt-1 is expressed in the tail neuron PVT, and in uterine cells; since exogenous melatonin slows C. elegans locomotion and enhances slowing by food, Y74C9A.3 may inhibit locomotion.
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