Caenorhabditis elegans
BLI-3
CELE_F56C11.1, tag-31, duox-1, F56C11.1
bli-3 encodes an NADPH oxidases of the dual oxidase (DUOX) variety that contains an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis.
GO Process (11)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
- body morphogenesis [IMP]
- collagen and cuticulin-based cuticle development [IGI, IMP]
- cuticle development involved in collagen and cuticulin-based cuticle molting cycle [IGI]
- defense response [IMP]
- embryo development ending in birth or egg hatching [IMP]
- locomotion [IMP]
- molting cycle, collagen and cuticulin-based cuticle [IMP]
- nematode larval development [IGI, IMP]
- peptide cross-linking [IDA, IMP]
- post-embryonic body morphogenesis [IGI]
- response to oxidative stress [IGI]
Gene Ontology Molecular Function
Download Curated Data for this Protein
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- Interactors 6
- Interactions 6
- Network