CELE_Y37E3.4, Y37E3.4

moag-4 encodes a small protein that is evolutionarily highly conserved, containing a 4F5 domain predicted to have a helix-loop-helix secondary structure, moag-4 is orthologous to human SERF1A and SERF2 (OMIM: 603011, 605054); MOAG-4 is a general regulator of protein aggregation and proteotoxicity but it does not act on all disease-associated aggregation-prone proteins; MOAG-4 and human SERF proteins regulate polyglutamine aggregation in a similar manner; moag-4 acts cell autonomously on protein aggregation and presence of MOAG-4 drives aggregation-prone proteins toward a compact conformation preceding the formation of aggregates; MOAG-4 may drive aggregation by acting on soluble aggregation-prone proteins directly or by regulating a signaling pathway; MOAG-4 enhances aggregation either downstream or in parallel to hsf-1 and daf-16; presence of MOAG-4 enhances the toxicity of polyglutamine; MOAG::4Cherry is excluded from Polyglutamine aggregates.

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