CELE_Y71F9B.4, 1D295, Y71F9B.4

snr-7 encodes the C. elegans ortholog of the small nuclear ribonucleoprotein G, one of seven subunits of the heptameric Sm complex required for the biogenesis and function of snRNPs that catalyze mRNA splicing; in addition to its predicted role in pre-mRNA processing, SNR-7 activity is essential for embryogenesis and for several aspects of germ cell specification including localization and subcellular distribution of P granules and maintenance of transcriptional quiescence; snr-7 is also required for RNA interference and for the overall health and fertility of the animal; immunostaining of adults and embryos using antibodies raised against mammalian Sm proteins and mammalian SmG, in particular, suggests that SNR-7 localizes to the nucleus and cytoplasm in many cell types, as well as to P granules in germ cells and their embryonic precursors.

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