CELE_Y71F9B.7, Y71F9B.7

plk-2 encodes one of three C. elegans polo-like kinases; in the developing germ line, PLK-2 activity is required for regulation of chromosome dynamics that result in recruitment and attachment of meiotic chromosomes to the nuclear envelope and cytoskeleton; in the early embryo, PLK-2 activity is required for regulating the function of MEX-5/6, zinc-finger proteins essential for embryonic polarity and with which PLK-2 interacts, via its polo box domain, in yeast two-hybrid assays; PLK-2 is expressed in the meiotic germ line where it initially localizes to pairing centers and later localizes to synaptonemal complexes and in early embryos where it localizes asymmetrically to the cytoplasm of somatic blastomeres; in the mitotic germline faint PLK-2 is seen faintly centrosomes and kinetochores.

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