CELE_Y71F9AL.16, Y71F9AL.16

arx-1, also called as Arp-3, encodes a subunit of the actin-related protein of the conserved Arp2/3 complex with 60% amino acid similarity to the homologous genes from human (OMIM: 604222); arx-1 is an essential gene as disruption in the expression by RNAi results in embryonic arrest due to ventral enclosure defects during morphogenesis; in Arp2/3-depleted embryos, the leading edge of the migrating epidermis lacks a normal enrichment of filamentous actin and finger-like protrusions; in migrating excretory cells, Arp2/3 is involved in longitudinal migration; WSP-1 and the Arp2/3 complex associate and function cell autonomously at cell boundaries during ventral enclosure; localization of WSP-1 is dependent on the Arp2/3 complex; expression of WSP-1 increases by the reduction of functional ARX-1.

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