CELE_Y47G6A.8, Y47G6A.8

crn-1 encodes a cell death-related nuclease and is a 5'-3' exonuclease, a protein homologous to mammalian flap endonuclease 1 (FEN1); crn-1 also has endonuclease activity; crn-1 is essential for embryonic development and promotes cell death; CRN-1 binds the endonuclease CPS-6 in interaction experiments and each of these proteins can enhance the others's endonuclease activity; crn-1 is believed to function in a large multinuclease complex, the degradeosome, whose components include the protein products of cps-6, crn-5, crn-4, cpy-13 and other non-nuclease components like wah-1, to promote apoptotic DNA degradation; crn-1 is ubiquitously expressed and localizes to the nucleus.

37393

6239