Caenorhabditis elegans
UNC-108
CELE_F53F10.4, unc-67, rab-2, F53F10.4
unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; unc-108 function is required in neurons for normal locomotion; unc-108 also functions in the removal of apoptotic cells, specifically it functions in engulfing cells for the recruitment and fusion of the lysosome to the phagosome; unc-108 is expressed in neurons and in engulfing cells.
GO Process (11)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- apoptotic cell clearance [IMP]
- embryo development ending in birth or egg hatching [IMP]
- engulfment of apoptotic cell [IMP]
- growth [IMP]
- locomotion [IMP]
- nematode larval development [IMP]
- phagolysosome assembly [IMP]
- phagolysosome assembly involved in apoptotic cell clearance [IGI, IMP]
- phagosome acidification involved in apoptotic cell clearance [IGI, IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 8
- Interactions 12
- Network